1. A miserable person; one profoundly unhappy. "The wretch that lies in woe." Shak. Hovered thy spirit o'er thy sorrowing son, Wretch even then, life's journey just begun Cowper. 2. One sunk in vice or degradation; a base, despicable person; a vile knave; as, a profligate wretch. Note: Wretch is sometimes used by way of slight or ironical pity or contempt, and sometimes to ex...