1. Malice; malignity; spite; malicious anger; contemptuous hate. With all thy despite against the land of Israel. Ezek. xxv. 6. 2. An act of malice, hatred, or defiance; contemptuous defiance; a deed of contempt. A despite done against the Most High. Milton. In despite, in defiance of another's power or inclination. -- In despite of, in defia...